AICAR 50mg

Buy AICAR UK (Acadesine): The Premier AMPK Activator for Metabolic Research

AICAR 50mg, also known as Acadesine, is a cell-permeable adenosine analogue and the most widely recognized pharmacological activator of AMP-activated protein kinase (AMPK). With a molecular weight of 258.23 g/mol and a CAS number of 2627-69-2, this high-purity compound (≥98%) serves as an indispensable tool for investigating cellular energy homeostasis, metabolic regulation, and a broad spectrum of signaling pathways.

Mechanism of Action

AICAR functions as an AMP mimetic. Upon cellular uptake, it is phosphorylated by adenosine kinase to ZMP, an analogue of AMP that directly and selectively activates AMPK without altering the cellular levels of ATP, ADP, or AMP. AMPK is a heterotrimeric serine/threonine kinase that serves as the master regulator of cellular and whole-body energy metabolism.

When energy status is low (indicated by a high AMP:ATP ratio), AMPK is naturally activated to restore balance by stimulating catabolic pathways that produce ATP while inhibiting anabolic pathways that consume it. It bypasses this physiological energy-sensing mechanism to directly and potently activate AMPK, making it an invaluable research agent.

The Critical Importance of AICAR 50mg in Modern Research

AICAR Peptide is not merely a compound; it is a catalyst for breakthrough discoveries across multiple scientific disciplines. Its importance in current research stems from its unique biochemical properties and its ability to interact with specific cellular pathways. Whether your laboratory is investigating metabolic signaling, tissue regeneration, or cellular longevity, it provides a robust model for understanding complex biological interactions.

Research Mechanism: How AICAR Functions

The biological activity is defined by its molecular structure and its affinity for specific cellular targets. At the biochemical level, this peptide acts as a ligand, binding to receptors to trigger intracellular cascades. Researchers utilize AICAR to map these pathways, observing the downstream effects on protein expression, cellular metabolism, or structural remodeling. The structural integrity is paramount; even minor impurities can lead to skewed data. That is why our synthesis process involves rigorous filtration and lyophilization to maintain a 99%+ purity profile.

Primary Research Benefits and Applications

Research into AICAR Peptide has revealed a broad spectrum of potential applications. By integrating this peptide into your protocols, your laboratory can explore the following benefits:

• Targeted Cellular Interaction: It is specifically engineered to interact with precise biological markers, making it an essential reagent for site-specific research.
• Enhanced Data Reproducibility: Due to the 100% accurate sequential fingerprint of our peptides, researchers can expect reproducible results across multiple trial phases.
• Versatile Study Frameworks: It is suitable for a variety of in vitro and in vivo models, ranging from metabolic syndrome studies to regenerative medicine research.

Rigorous Quality Assurance: The Peptide Sciences Labs Standard

At Peptide Sciences LLC, we implement the most stringent quality control standards in the industry. From the initial synthesis to the final vacuum-sealing process, it is monitored for purity and stability. Every batch is subjected to High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) analysis.

Key Research Applications

Metabolism and Endocrinology: It potently stimulates glucose uptake in skeletal muscle through an insulin-independent mechanism—a pathway that cannot be blocked by PI3K inhibitors. Concurrently, it enhances fatty acid oxidation in muscle while inhibiting fatty acid and cholesterol synthesis in the liver. These properties position as a critical tool for investigating type 2 diabetes, obesity, hypercholesterolemia, and non-alcoholic fatty liver disease.

Inflammation and Immunity: It suppresses the production of pro-inflammatory cytokines, including TNFα, IL-1β, IL-6, and IL-8, and inhibits iNOS expression. This makes it a valuable agent for exploring inflammatory pathways and immune modulation.

Stem Cell and Developmental Biology: It upregulates pluripotency network genes (Klf4, Klf2, Nanog, Oct4, Sox2) in mouse embryonic stem cells. It promotes osteogenic differentiation while inhibiting adipogenic differentiation in mesenchymal stem cells, and directs neural stem cells toward astrocytic differentiation.

Cancer Research: Recent studies demonstrate that It induces apoptosis and increases DNA damage in EGFR-mutant lung cancer cell lines by disrupting MUC1 protein-protein interactions.

Emerging Applications: It has shown promise in models of ischemic/reperfusion injury, renal protection, hypertension, muscle wasting, diabetic neuropathy, and even neurogenesis and depression-like behaviors.

Product Specifications and Quality

It is provided as a white to off-white powder with ≥98% purity verified by HPLC. It is soluble in water (>7 mg/mL), DMSO (20 mg/mL), methanol (10 mg/mL), and ethanol (1 mg/mL). For optimal stability, store the powder at -20°C, protected from light. Solutions prepared in DMSO can be stored at -20°C for up to three months.

Important Notice

This product is manufactured exclusively for in vitro research purposes and is not intended for diagnostic or therapeutic use in humans or animals. It is not approved by the FDA and is prohibited by the World Anti-Doping Agency (WADA) for use in athletic competition. All handling should be performed with appropriate personal protective equipment in a laboratory setting.

Unlock the full potential of your metabolic and signaling research —the gold-standard AMPK activator trusted by scientists worldwide.