FOX04-DRI 10mg

Buy FOX04-DRI Online –The Senolytic Peptide for Advanced Research

FOX04-DRI (also known as FOXO4-DRI) is a cutting-edge, cell-permeable peptide antagonist specifically designed for senescence research. As a synthetic D-retro-inverso peptide, it represents a modified version of the FOXO4 protein, engineered to prolong its half-life and enhance its stability for research applications. With a CAS number of 2460055-10-9 and a molecular weight of 5358.06, this high-purity peptide (typically 98-99%) is available as a white lyophilized powder, ideal for laboratory use.

Mechanism of Action

FOX04-DRI functions as a potent senolytic agent by competitively blocking the interaction between FOXO4 and the tumor suppressor protein p53. In senescent cells, the FOXO4-p53 complex helps these “zombie” cells resist apoptosis. By disrupting this complex, FOX04-DRI triggers the nuclear exclusion of active p53, redirecting it to the mitochondria to induce cell-intrinsic apoptosis. This mechanism selectively eliminates senescent cells while sparing normal, healthy cells, making it a highly targeted research tool.

Why Choose FOX04-DRI?

FOX04-DRI stands at the forefront of senolytic research, offering researchers a powerful tool to study cellular senescence, aging mechanisms, and therapeutic interventions. Its proven selectivity for senescent cells, combined with its ability to modulate critical pathways like insulin signaling, cell cycle regulation, and oxidative stress response, makes it an invaluable asset for advancing our understanding of age-related diseases and cancer biology. Whether investigating the fundamental biology of aging or developing novel therapeutic strategies, FOX04-DRI provides the precision and reliability that cutting-edge research demands.

In the field of regenerative medicine, few compounds have generated as much interest as FOX04-DRI. Often referred to as Proxofim, this peptide acts as a targeted senolytic. Its job is simple but profound: it disrupts the interaction between the FOX04 protein and p53. In damaged cells—often called “zombie cells” this bond is what prevents the cell from dying naturally.

Why Researchers Are Studying FOX04-DRI 10mg

Most research peptides focused on aging attempt to repair damage, but FOXO4-DRI is unique because it focuses on removal. When senescent cells linger, they secrete inflammatory signals that damage neighboring healthy cells.

Animal models have shown that clearing these cells can lead to:

• Restored Organ Function: Specifically in the kidneys and liver.

• Improved Vitality: Observations of increased physical activity and fur density in murine studies.

• Reduced Inflammation: Lowering the systemic “noise” caused by aging cells.

Technical Superiority and Purity

When you look to buy research peptides, the structural integrity of the molecule is everything. Our FOX04-DRI is a “Retro-Inverso” peptide. This means the sequence is reversed and uses D-amino acids, which makes it much harder for natural enzymes to break down. This results in a compound that stays active in your research environment far longer than the base FOX04 protein.

Trust the Peptide Sciences Labs

High-stakes research requires high-purity materials. We don’t just claim quality; we prove it.

1. Verified Purity: Every 10mg vial is tested to ensure 99%+ purity.

2. Full Documentation: COAs and HPLC-MS results are available for every batch.

3. Budget Conscious: Use a Peptide Sciences coupon at checkout to help manage your laboratory’s overhead on bulk orders.

Whether you are investigating insulin sensitivity or the reversal of biological aging markers, our FOX04-DRI provides the stability and precision you need.

Note: This product is intended for laboratory research use only. Not for human or animal consumption. Ensure all safety protocols are followed in your facility.

Research Applications and Key Findings

FOX04-DRI has demonstrated remarkable potential across multiple research areas:

· Senescence and Aging: Studies show that FOX04-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice, improving the testicular microenvironment and reversing aspects of biological aging.

· Cancer Radiosensitization: In non-small cell lung cancer (NSCLC) research, FOX04-DRI increases radiosensitivity by promoting apoptosis, reducing cell proliferation, and decreasing cell migration. It induces G₀/G₁ cell cycle arrest and enhances the effects of radiation therapy.

· Fibrosis and Oxidative Stress: FOX04-DRI reduces oxidative stress and inhibits cellular senescence through activation of the PI3K/AKT signaling pathway, showing promise in reversing radiation-induced pulmonary fibrosis.

· Cartilage and Joint Health: Research indicates FOX04-DRI can selectively remove senescent cells from expanded human chondrocytes, suggesting applications in osteoarthritis research.

Product Specifications

· CAS Number: 2460055-10-9
· Molecular Formula: C₂₂₈H₃₃₈N₈₆O₆₄
· Purity: 98-99% (HPLC)
· Appearance: White to off-white lyophilized powder
· Solubility: DMSO (50 mg/mL)
· Storage: Sealed, protected from moisture, below -20°C for long-term storage

Amino Acid Sequence

D-(LTLRKEPASELAGSILEAYSONGWANFRSGGKRPPPRRRQRKKRG)

Handling and Usage

For optimal solubility, warm the vial to 37°C and use an ultrasonic bath. Stock solutions can be stored below -20°C for several months. FOX04-DRI is supplied as a research-grade reagent and is strictly intended for laboratory use only—not for human therapeutic applications.